Cite as: Cold Spring Harb. Protoc.; 2008; doi:10.1101/pdb.emo101

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emoEmerging Model Organisms

Planarians: A Versatile and Powerful Model System for Molecular Studies of Regeneration, Adult Stem Cell Regulation, Aging, and Behavior

Néstor J. Oviedo, Cindy L. Nicolas, Dany S. Adams, and Michael Levin1

Center for Regenerative and Developmental Biology, Forsyth Institute and Developmental Biology Department, Harvard School of Dental Medicine, Boston, MA 02115, USA

1Corresponding author (mlevin{at}forsyth.org)


INTRODUCTION

In recent years, planarians have been increasingly recognized as an emerging model organism amenable to molecular genetic techniques aimed at understanding complex biological tasks commonly observed among metazoans. Growing evidence suggests that this model organism is uniquely poised to inform us about the mechanisms of tissue regeneration, stem cell regulation, tissue turnover, pharmacological action of diverse drugs, cancer, and aging. This article provides an overview of the planarian model system with special attention to the species Schmidtea mediterranea. Additionally, information is provided about the most popular use of this organism, together with modern genomic resources and technical approaches.


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This article has been cited by other articles:


Home page
 CSH ProtocolsHome page
N. J. Oviedo, C. L. Nicolas, D. S. Adams, and M. Levin
Establishing and Maintaining a Colony of Planarians
CSH Protocols, October 1, 2008; 2008(11): pdb.prot5053 - pdb.prot5053.
[Abstract] [Full Text]

Home page
 CSH ProtocolsHome page
N. J. Oviedo, C. L. Nicolas, D. S. Adams, and M. Levin
Gene Knockdown in Planarians Using RNA Interference
CSH Protocols, October 1, 2008; 2008(11): pdb.prot5054 - pdb.prot5054.
[Abstract] [Full Text]

Home page
 CSH ProtocolsHome page
N. J. Oviedo, C. L. Nicolas, D. S. Adams, and M. Levin
Live Imaging of Planarian Membrane Potential Using DiBAC4(3)
CSH Protocols, October 1, 2008; 2008(11): pdb.prot5055 - pdb.prot5055.
[Abstract] [Full Text]