Emerging Model Organisms

Cephalochordates (Amphioxus or Lancelets): A Model for Understanding the Evolution of Chordate Characters

¹ Institute of Cellular and Organismic Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan, Republic of China
² Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, USA

³Corresponding author (jkyu{at}gate.sinica.edu.tw).

INTRODUCTION

Cephalochordates, commonly called amphioxus or lancelets, are marine invertebrate chordates. They were traditionally held as the closest living relatives of vertebrates and have long occupied a key phylogenetic position in our discussions on the origin of vertebrates. However, recent molecular phylogenetic analyses have placed tunicates as the sister taxon of vertebrates and cephalochordates as the most basal chordate group. Therefore, studies on cephalochordates can also provide important insights for understanding the conserved patterning mechanisms for all chordates. Cephalochordates and vertebrates share several key chordate features, namely, the dorsal nerve cord, notochord, segmented somites, and pharyngeal gill slits. However, vertebrates have ~25% more genes than amphioxus and several features not present in cephalochordates, including a more elaborate head and forebrain, migratory neural crest, and neurogenic placodes. During the last two decades, expression patterns of important developmental genes have been used extensively to infer homologies between cephalochordate and vertebrate embryos. These studies have answered some long-standing questions concerning the evolution of vertebrates from their invertebrate ancestors and have also generated interesting hypotheses for further investigations. With the completion of a cephalochordate genome project in 2008, comparison between cephalochordate and vertebrate genomes has allowed us to postulate a picture for the genome of the last common ancestor of all chordates. Such comparisons are also providing important biological insights into the functional biology of cephalochordates and the evolutionary origin of developmental mechanisms that led to the emergence of the vertebrate body plan.