Cite as: Cold Spring Harb. Protoc.; 2010; doi:10.1101/pdb.emo139

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emoEmerging Model Organisms

The Rabbit (Oryctolagus cuniculus): A Model for Mammalian Reproduction and Early Embryology

Bernd Püschel1, Nathalie Daniel2, Eva Bitzer3, Martin Blum3, Jean-Paul Renard2, and Christoph Viebahn1,4

1 Department of Anatomy and Embryology, University of Göttingen, 37075 Göttingen, Germany
2 Unité Mixte de Recherche UMR 1198, Biologie du Développement et Reproduction, Institut National de la Récherche Agronomique, F-78350 Jouy-en-Josas, France
3 Department of Zoology, University of Hohenheim, 70593 Stuttgart, Germany

4Corresponding author (cviebah{at}gwdg.de).


INTRODUCTION

The rabbit is a valuable animal model for a variety of biomedical research areas including in vitro fertilization, early embryology and organogenesis, neurophysiology, ophthalmology, and cardiovascular research. The rabbit is also used as a model for toxicology studies and analyses of drug effects on embryo and fetal development, as well as for research involving the immune system (e.g., host/pathogen interactions, asthma, arthritis, systemic lupus erythematosus). The rabbit’s most prominent use as a laboratory animal is antibody production; most biomedical research institutions thus provide the infrastructure and veterinary expertise for keeping rabbits. This article discusses current advances in applying modern life science research methods to basic and applied embryological research using the rabbit as a model for early intrauterine development in mammals, including state-of-the-art genomic tools and the sequencing data available (and planned) for the rabbit.


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This article has been cited by other articles:


Home page
 Cold Spring Harb ProtocHome page
B. Puschel and C. Viebahn
Rabbit Mating and Embryo Isolation
Cold Spring Harb Protoc, January 1, 2010; 2010(1): 10.1101/pdb.prot5350.
[Abstract] [Full Text]

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Cold Spring Harb Protoc, January 1, 2010; 2010(1): 10.1101/pdb.prot5351.
[Abstract] [Full Text]

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 Cold Spring Harb ProtocHome page
B. Puschel, E. Bitzer, and C. Viebahn
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 Cold Spring Harb ProtocHome page
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Cold Spring Harb Protoc, January 1, 2010; 2010(1): 10.1101/pdb.prot5353.
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NIAID rabbit lines
Rose G. Mage
Cold Spring Harb Protoc, 27 Jan 2010 [Full text]