Topic Introduction

Two-Photon Imaging of Neural Activity in Awake Mobile Mice

  1. David Tank
Adapted from Imaging in Neuroscience (ed. Helmchen and Konnerth). CSHL Press, Cold Spring Harbor, NY, USA, 2011.

Abstract

A method for functional, cellular-resolution imaging of neural populations in awake and mobile mice is presented here. The method is based on the use of a spherical treadmill, head restraint, and motion correction software that facilitate neural imaging in the awake brain with a fixed upright two-photon microscope. These approaches have proven to be applicable to a wide range of brain regions and should help further our understanding of how neuronal population activity within the brain’s microcircuitry is connected to animal behavior.

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  1. doi:10.1101/pdb.top081810 Cold Spring Harb Protoc 2014: pdb.top081810- © 2014 Cold Spring Harbor Laboratory Press
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