The endosome/lysosome system. Internalized macromolecules and solutes are delivered to early endosomes through several internalization routes. From early endosomes, cargo can be further transported to several intracellular compartments such as recycling endosomes, plasma membrane, multivesicular body (MVB), late endosomes, and the trans-Golgi network (TGN). ER, endoplasmic reticulum.