Table 1.
Published RCAS-TVA animal models
| Targeted tissue type | Promoter | Tumor types | Reference |
|---|---|---|---|
| All tissues | β-actin | Ovarian cancer | Federspiel et al. 1996 |
| All tissues | LSL-UBC-GFP-TVA | n.a. | Beier et al. 2011 |
| All tissues (w/appropriate cre driver) | LSL-Rosa26 | Pancreatic ductal adenocarcinoma | Seidler et al. 2008 |
| CNS progenitors | Olig2 | Medulloblastoma | Schuller et al. 2008 |
| Endothelial cells | Flk1 | n.a. | Vervoort et al. 2008 |
| Columnar epithelium | Keratin19 | Pancreatic cancer, breast cancer | Morton et al. 2007 |
| Glial cells | GFAP | Glioma | Holland et al. 1998 |
| Glial progenitor cells | Nestin | High-grade gliomas, medulloblastoma | Holland et al. 2000 |
| Hematopoetic progenitors | SCL (Tal1) | Hemangioma | Sausville et al. 2008 |
| Hepatocytes | Albumin | Hepatocellular carcinoma, cholangiocarcinoma | Lewis et al. 2005 |
| Keratinocytes, ovarian surface epithelium | Keratin5 | Ovarian cancer | Orsulic et al. 2002 |
| Mammary gland epithelium | MMTV | Breast cancer | Du et al. 2006 |
| Mammary luminal epithelium | Keratin 6a | Normal-like breast cancer | Bu et al. 2011 |
| Megakaryocytes | GP-Iba | n.a. | Murphy and Leavitt 1999 |
| Megakaryocytes | GPIIb/ITGA2B | n.a. | Gaur et al. 2001 |
| Melanoblasts | Dopachrome tautomerase | Melanoma | Dunn et al. 2000 |
| Neural crest stem cells | Pax3 | n.a. | Hou et al. 2004 |
| Oligodendrocytes | CNP | Glioma | Lindberg et al. 2009 |
| Pancreatic acinar cells | Elastase | Acinar, ductal carcinoma; endocrine tumors | Lewis et al. 2003 |
| Pancreatic β-cells | Rat Insulin Promoter | Pancreatic islet tumor | Du et al. 2007 |
| Skeletal tissue | BSP | n.a. | Li et al. 2005 |
| Skeletal/cardiac smooth muscle cells | Alpha-sk-actin (chicken) | n.a. | Federspiel et al. 1994 |
| Vascular endothelial cells | TIE2 | Kaposi’s sarcoma | Montaner et al. 2003 |
