Table 1.
Caspase cleavage motifs
| Determination of cleavage motif | ||||
|---|---|---|---|---|
| Caspase | Prediction from structurea | Substrate cleavage site in cell cultureb | Peptide cleavage by isolated caspasec | Peptide cleavage more effective by listed caspaseb |
| 1 | WEHD | N/A | WEHD | N/A |
| 2 | DEXD | XXXD | VDVAD | 3 |
| 3 | DE(A/V)D | DEVD | DEVD | 3 |
| 6 | (L/I/V)E(A/V)D | (E/I/V)EVD | VEID | 3 |
| 7 | DE(A/V)D | D(E/Q)VD | DEVD | 3 |
| 8 | (L/I/V)EXD | LEVD | IETD | 3, 6 |
| 9 | (L/I/V)EXD | XEVD | LEHD | 3, 6, 8 |
| 10 | (L/I/V)EXD | XEVD | IETD | 3, 6 |
-
X represents any amino acid.
-
aBased on Chereau et al. 2003.
-
bBased on McStay et al. 2008.
-
cBased on Thornberry et al. 1997.
