ECR browser analysis of the IRF6-C1orf107 30 kb human locus conservation. The comparative analysis was performed with chimp, cow, mouse, opossum, fugu, chicken, and frog (A) and in opossum and mouse (B). The standard 100 bp/70% identity threshold has been used to identify 24 human intergenic CNS (A), and a strict—core ECRs (350 bp/77% identity)—threshold was used to identify the sole well-conserved human-mouse CNS in the locus (B). Gray vertical lines in the middle of the plot indicate the position of the disease SNP, rs642961.