Cover image

Transmission electron micrograph of an apoptotic HaCaT cell 6 h after treatment with 25 µM siramesine. Siramesine triggers apoptosis via a mechanism that is independent of lysosomal membrane permeabilization (LMP). In this issue, Urška Repnik, Maruša Hafner Česen, and Boris Turk present methods for exploring LMP (e.g., see doi: 10.1101/pdb.prot087106). Image courtesy of Urška Repnik.