Long-Term Potentiation by Theta-Burst Stimulation Using Extracellular Field Potential Recordings in Acute Hippocampal Slices
- 1Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montréal General Hospital, Montréal, Québec H3G 1A4, Canada;
- 2Integrated Program in Neuroscience, McGill University, Montréal, Quebec H3A 2B4, Canada;
- 3Department of Biology, Bellini Life Sciences Building, McGill University, Montréal, Québec H3G 0B1, Canada
Abstract
This protocol describes how to carry out theta-burst long-term potentiation (LTP) with extracellular field recordings in acute rodent hippocampal slices. This method is relatively simple and noninvasive and provides a way to sample many neurons simultaneously, making it suitable for applications requiring higher throughput than whole-cell recording.
Footnotes
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↵4 Correspondence: jesper.sjostrom{at}mcgill.ca
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From the Ion Channels collection, edited by Paul J. Kammermeier, Ian Duguid, and Stephan Brenowitz.
- © 2016 Cold Spring Harbor Laboratory Press
