Topology of the phylogenetic relationship among yeast isolates. The relationships of the main lineages of S. cerevisiae isolates are displayed without all strains indicated. The topology shown is adapted from the SGRP analysis of whole-genome sequences (Liti et al. 2009) and the analysis of nine concatenated gene sequences for the Chinese isolates (Wang et al. 2012). The main lineages from the SGRP analysis are North American (NA), Wine/European (WE), Sake (SA), West African (WA), and Malaysian (MA). The Chinese analysis revealed eight new populations (CHN I through VIII), some of which are closely related to the previously known lineages, whereas some are more diverse. The cloud represents the known whole-genome sequence space of S. cerevisiae as a species. The majority of laboratory strains fall into the small circular area within the cloud. The exceptions being SK1 and Y55, which fall close the WA population.