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Gray-scale fluorescent image of the contents of a germinal vesicle (GV), including lampbrush chromosomes and nuclear bodies, from a Xenopus oocyte. In this issue, Garry Morgan details procedures for isolating GVs from Xenopus oocytes and analyzing them in combination with fluorescent reporter proteins (doi: 10.1101/pdb.prot096958). Image courtesy of Garry T. Morgan.