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High-resolution confocal image of a Xenopus laevis embryonic neuronal growth cone showing localization of fluorescently tagged microtubule plus-end binding protein. A single growth cone image is pseudocolored and organized. In this issue, Laura Anne Lowery and colleagues provide a protocol for live imaging of cytoskeletal dynamics in neuronal growth cones and neural crest cells from X. laevis embryos (doi: 10.1101/pdb.prot104463). Image courtesy of Burcu Erdogan (Lowery Lab).