Table 7.

Suggested doses of immunogens in rabbits

Form of antigen	Examples	Possible routes^a	Dose (μg)
Soluble proteins	Enzymes	s.c., i.m., i.d., i.v.	50–1000
	Carrier proteins conjugated with peptides
	Immune complexes
Particulate proteins	Viruses (killed)	s.c., i.m., i.d.	50–1000
	Yeast (killed)
	Bacteria (killed)
	Structural proteins
Insoluble proteins	Bacterially produced from inclusion bodies	s.c., i.m., i.d.	50–1000
Insoluble proteins	Immunopurified proteins bound to beads	s.c., i.m., i.d.	50–1000
Carbohydrates	Polysaccharides	s.c., i.m., i.d., i.v.	50–1000
Carbohydrates	Glycoproteins	s.c., i.m., i.d., i.v.	50–1000
Nucleic acids	Carrier proteins conjugated with nucleic acids	s.c., i.m., i.d., i.v.	50–1000

^as.c., subcutaneous; i.m., intramuscular; i.d., intradermal; i.v., intravenous.