Topic Introduction

Mapping Billions of Short Reads to a Reference Genome

  1. Zhiping Weng

Abstract

Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.

Footnotes

  • From the Molecular Cloning collection, edited by Michael R. Green and Joseph Sambrook.

This Article

  1. Published in Advance August 29, 2016, doi: 10.1101/pdb.top093153 Cold Spring Harb Protoc © 2017 Cold Spring Harbor Laboratory Press
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