Topic Introduction

Mapping Billions of Short Reads to a Reference Genome

  1. Zhiping Weng

Abstract

Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.

Footnotes

  • From the Molecular Cloning collection, edited by Michael R. Green and Joseph Sambrook.

Articles citing this article

This Article

  1. Published in Advance August 29, 2016, doi: 10.1101/pdb.top093153 Cold Spring Harb Protoc © 2017 Cold Spring Harbor Laboratory Press
  1. » Abstract
  2. Full Text (PDF)
  3. All Versions of this Article:
    1. pdb.top093153v1
    2. 2017/1/pdb.top093153 most recent

Article Category

  1. Topic Introduction

Personal Folder

  1. Save to Personal Folders

Updates/Comments

  1. Submit Updates/Comments
  2. No Updates/Comments published
  3. Alert me when Updates/Comments are published

Share

Current Issue

  1. January 2026, 2026 (1)
  1. Current Issue