| Mos |
Null phenotype, parthenogenetic activation of MII eggs, infertility |
Stein et al. 2003 |
| Msy2 |
Pleiotropic effect, defects in protein synthesis, abnormal GV oocytes, severely reduced fertility |
Yu et al. 2004 |
| Bnc |
Pleiotropic maternal effect phenotype, morphological abnormalities in the oocyte, perturbation of pol I and pol II transcription,
no development beyond the two-cell stage, subfertility
|
Ma et al. 2006 |
| Wee1b |
Relief of meiotic arrest (GVBD induction) in 25% of the oocytes |
Han et al. 2005 |
| Ctcf |
Aberrant methylation of H19 imprinting locus, decreased developmental competence |
Fedoriw et al. 2004 |
| Plcb1 |
Significant decrease in Ca2+ transient amplitude, but not duration or frequency, in eggs following insemination
|
Igarashi et al. 2007 |
| H1foo |
Strong knockdown, no phenotype (knock-out has also no phenotype) |
Stein et al. 2005 |
| Cpeb |
Parthenogenetic cell division in the ovary, abnormal polar bodies, oocytes with spindle and nuclear anomalies, detached from
the cumulus granulosa cell layer, many follicles contain apoptotic granulosa cells. Gdf9 RNA has a shortened poly(A) tail and reduced expression
|
Racki and Richter 2006 |
| Slbp |
Two-cell arrest, histones H3 and H4, but not H2A or H2B, substantially reduced in these embryos. |
Arnold et al. 2008 |
|
| Abbreviations: GV: germinal vesicle; GVBD, GV breakdown; MII: metaphase II. |
